Abstract
WHEN cells are lysed by antibody and complement (C), uniform bubbles or “holes” revealed by negative staining in the electron microscope appear at the surface. These lesions are probably due to micelle formation in the surface lipid layer (evidence reviewed in ref. 1). C activated by antibody through C8 has also been shown to damage liposomes containing Forssman antigen in their lipid membranes2,3, though not to make holes in them4. C activated in the “reactive lysis” system (involving attachment to erythrocyte membranes or other hydrophobic surfaces of an unstable C&567bar; complex which in turn interacts with C8 and C95) causes typical lesions in erythrocyte membranes6 and in lecithin liposomes7.
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HESKETH, T., DOURMASHKIN, R., PAYNE, S. et al. Lesions due to Complement in Lipid Membranes. Nature 233, 620–623 (1971). https://doi.org/10.1038/233620a0
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DOI: https://doi.org/10.1038/233620a0
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