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Hormonal Pregnancy Tests and Neural Tube Malformations

Abstract

IN 1967 Gal, Kirman and Stern1 reported a possible relationship between pregnancy tests using pills containing synthetic oestrogenic and progesterogenic hormones and the birth of a child with spina bifida. Of the 100 mothers of children with spina bifida, nineteen gave a history of pregnancy diagnosis by this means; only four of the 100 matched control mothers gave such a history.

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  1. Gal, I., Kirman, B., and Stern, J., Nature, 216, 83 (1967).

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LAURENCE, M., MILLER, M., VOWLES, M. et al. Hormonal Pregnancy Tests and Neural Tube Malformations. Nature 233, 495–496 (1971). https://doi.org/10.1038/233495b0

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