Abstract
METHADONE maintenance was reported as a treatment for heroin addiction in 19651, and more than 10,000 patients are now maintained on the drug at more than 100 centres throughout the United States (unpublished Lilly Survey, 1970). Wallach et al.2 observed that although women experienced abnormal menses during heroin addiction, regular menstruation and ovulation resumed with daily methadone treatment. In these studies several pregnancies were followed in which methadone maintenance was initiated before or during pregnancy with no apparent effect.
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References
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MARKHAM, J., EMMERSON, J. & OWEN, N. Teratogenicity Studies of Methadone HCl in Rats and Rabbits. Nature 233, 342–343 (1971). https://doi.org/10.1038/233342a0
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DOI: https://doi.org/10.1038/233342a0
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