Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Decreased Feeding after Injections of Amino-acids into the Hypothalamus

Abstract

BUT for two exceptions1,2, attempts to inhibit feeding behaviour by direct intrahypothalamic administration of glucose have been unsuccessful3–6. The effects of other nutrients have yet to be assessed. We have found that microinjections of balanced amino-acid solutions into dorsolateral perifornical hypothalamic tissue, where consummatory behaviours are obtained with electrical stimulation, inhibit feeding in rats.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Herberg, L. J., Nature, 187, 245 (1960).

    Article  ADS  CAS  Google Scholar 

  2. Booth, D. A., J. Comp. Physiol. Psychol., 65, 13 (1968).

    Article  CAS  Google Scholar 

  3. Epstein, A. N., Amer. J. Physiol., 199, 969 (1960).

    CAS  Google Scholar 

  4. Wagner, J. W., and DeGroot, J., Amer. J. Physiol., 204, 483 (1963).

    CAS  PubMed  Google Scholar 

  5. Fisher, A. E., Sci. Amer. 210, 60 (1964).

    Article  CAS  Google Scholar 

  6. Grossman, S. P., Fed. Proc., 27, 1349 (1968).

    CAS  PubMed  Google Scholar 

  7. Valenstein, E. S., Cox, V. C., and Kakolewski, J. W., Psych. Rev., 77, 16 (1970).

    Article  CAS  Google Scholar 

  8. Adair, E. R., Miller, N. E., and Booth, D. A., Commun. Behav. Biol., 2, 25 (1968).

    Google Scholar 

  9. Panksepp, J., Psychon. Monog. Suppl. (in the press).

  10. Henschen, A., and Söderberg, U., in Structure and Function of Inhibitory Neuronal Mechanisms (edit. by von Euler, C., Skoglund, S., and Söderberg, U.) (Pergamon, Oxford, 1968).

    Google Scholar 

  11. Werman, R., Davidoff, R. A., and Aprison, M. H., Nature, 214, 681 (1967).

    Article  ADS  CAS  Google Scholar 

  12. Curtis, D. R., Hösli, L., Johnston, J. H., and Johnston, G. A. R., Exp. Brain Res., 5, 235 (1968).

    Article  CAS  Google Scholar 

  13. Curtis, D. R., Hösli, L., and Johnston, G. A. R., Exp. Brain Res., 6, 1 (1968).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

PANKSEPP, J., BOOTH, D. Decreased Feeding after Injections of Amino-acids into the Hypothalamus. Nature 233, 341–342 (1971). https://doi.org/10.1038/233341a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/233341a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing