Abstract
ALL kinds of human nucleated cells so far tested express on their surface the HL-A antigens which form the major histo-compatibility system in man1. These antigens, which are easily detected on lymphocytes and on platelets of peripheral blood, have also been found on other human cells2–9. In long term human cell cultures, it has been possible to demonstrate the remarkable stability of the HL-A antigens. Analogous observations have been reported in mouse regarding the antigens controlled by H-2 histocompatibility system10. We report here results obtained from the study of ten varieties of human fibroblasts, which enabled us to analyse the behaviour of the antigens of the HL-A system in cell cultures of limited duration11.
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SASPORTES, M., DEHAY, C. & FELLOUS, M. Variations of the Expression of HL-A Antigens on Human Diploid Fibroblasts in vitro. Nature 233, 332–334 (1971). https://doi.org/10.1038/233332a0
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DOI: https://doi.org/10.1038/233332a0
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