Abstract
Cerf and Chacko1 found that the number and diameter of motor neurone dendrites decreased after axotomy in the adult bullfrog. The purposes of the investigation reported here are to confirm and extend these observations in a mammal, to determine whether the dendritic changes are due to loss of axoplasm or loss of effective neuromuscular transmission, to see if dendrites recover after nerve regeneration has restored contact between the nerve and the originally innervated muscle mass, and if they recover after the regenerating nerve makes contact with different denervated muscle. Quantitative assessments of the dendritic spread of developing rat and human cortical neurones have been made by Eayrs and Goodhead2, and Schadé and van Groenigen3. Schapiro and Vukovitch4 found that the number of dendritic spines of rat cortical neurones could be influenced by variety of experience during development; Jones and Thomas5 and Matthews and Powell6 reported a decrease in the number and length of dendrites after deafferentation. Possible neuronal plasticity in the central nervous system of adult rats has been reported by Raisman7.
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References
Cerf, J. A., and Chacko, L. W., J. Comp. Neurol., 109, 205 (1958).
Eayrs, J. T., and Goodhead, B., J. Anat., 93, 385 (1959).
Schadé, J. P., and Van Groenigen, W. B., Acta Anat., 47, 74 (1961).
Schapiro, S., and Vukovitch, K. A., Science, 167, 292 (1970).
Jones, W. H., and Thomas, D. B., J. Anat., 96, 375 (1962).
Matthews, M. R., and Powell, T. P. S., J. Anat., 96, 89 (1962).
Raisman, G., Brain Res., 14, 25 (1969).
Sholl, D. A., J. Anat., 87, 387 (1953).
Watson, W. E., J. Physiol., 180, 741 (1965).
Watson, W. E., J. Physiol., 202, 611 (1969).
Watson, W. E., J. Physiol., 210, 321 (1970).
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SUMNER, B., WATSON, W. Retraction and Expansion of the Dendritic Tree of Motor Neurones of Adult Rats induced in vivo. Nature 233, 273–275 (1971). https://doi.org/10.1038/233273a0
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DOI: https://doi.org/10.1038/233273a0
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