Abstract
RECENT reports by Olney that monosodium glutamate (MSG) can cause acute neuronal necrosis in the developing brain of mice1–3, rats1 and monkeys4, have been the subject of intensive debate5–11. Some people9,11 deny that a single subcutaneous dose of monosodium glutamate can produce any brain damage in infant rats. Although Arees and Mayer10 confirm the existence of a necrotic lesion in both mouse and rat brain they restrict the pathology to “microglial” cells. None of these investigators attempted actually to replicate Olney's methods but used entirely different methods of preservation and staining.
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References
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BURDE, R., SCHAINKER, B. & KAYES, J. Acute Effect of Oral and Subcutaneous Administration of Monosodium Glutamate on the Arcuate Nucleus of the Hypothalamus in Mice and Rats. Nature 233, 58–60 (1971). https://doi.org/10.1038/233058a0
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DOI: https://doi.org/10.1038/233058a0
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