Abstract
THE inhibitory response of the rat uterus to adrenaline in the presence of isoprenaline inhibition can be reversed in induced oestrus but not in the progestational state, and it has been postulated that a motor substance accumulates during the isoprenaline inhibition and is released on addition of adrenaline1. The same sequence of events has also been observed when adrenaline was used as the initial inhibitory agent. The motor response to adrenaline is even more readily obtained in the late pregnant uterus but not in dioestrus2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Tothill, A., Nature, 213, 1230 (1967).
Tothill, A., Brit. J. Pharmacol., 29, 291 (1967).
Vane, J. R., Brit. J. Pharmacol., 12, 344 (1957).
Green, K., and Samuelsson, B., J. Lipid Res., 5, 117 (1964).
Levy, B., and Tozzi, S., J. Pharmac. Exp. Ther., 142, 178 (1963).
Davies, B. H., Horton, E. W., and Withrington, P. G., Brit. J. Pharmacol., 32, 127 (1968).
Shaw, J. E., Fed. Proc., 25, 770 (1966).
Ramwell, P. W., Shaw, J. E., and Kucharski, J., Science, 149, 1390 (1965).
Bergstrom, S., Eliasson, R., Von Euler, U. S., and Sjövall, J., Acta. Physiol. Scand., 45, 133 (1959).
Du Charme, D. W., and Weeks, J. R., Nobel Symp., 2, Prostaglandins, 173 (Almqvist and Wiksell, Stockholm 1966).
Butterworth, K. R., Brit. J. Pharmacol., 21, 378 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TOTHILL, A., RATHBONE, L. & WILLMAN, E. Relation between Prostaglandin E2 and Adrenaline Reversal in the Rat Uterus. Nature 233, 56–57 (1971). https://doi.org/10.1038/233056a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/233056a0
This article is cited by
-
High frequency radar observations of horizontal plasma waves in the equatorial ionosphere
Nature (1979)
-
The aeronomy experiment
Proceedings of the Indian Academy of Sciences Section C: Engineering Sciences (1978)
-
Aspirin and Indomethacin Prolong Parturition in Rats: Evidence that Prostaglandins Contribute to Expulsion of Foetus
Nature (1972)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.