Abstract
WE have recently overcome certain technical difficulties in applying the cytotoxicity test to mouse spermatozoa and have been able to show directly that H-2 antigens are expressed on these cells1, thus confirming less direct evidence leading to the same conclusion2. We have since applied the cytotoxicity test to sperm with antisera directed against a number of other systems of mouse alloantigens, TL3, θ4, Ly-A5 and Ly-B5, but none of these has given a positive reaction with sperm. This is not surprising because these are all “differentiation antigens”6 expressed primarily on lymphoid cells. Another antigenic system which distinguishes one mouse from another is H-Y. The H-Y antigen is carried by male cells only and is responsible for the rejection of male tissues by females of the same inbred strain7.
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GOLDBERG, E., BOYSE, E., BENNETT, D. et al. Serological Demonstration of H–Y (Male) Antigen on Mouse Sperm. Nature 232, 478–480 (1971). https://doi.org/10.1038/232478a0
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DOI: https://doi.org/10.1038/232478a0
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