Abstract
REPEATED administration of an opiate narcotic leads to the tolerant-dependent state. Previous communications1,2 from this laboratory have described the relationship between the degree of tolerance in mice and the dose, interval and duration of exposure to an opiate. Recently, jumping behaviour elicited by the opiate antagonist, naloxone, was shown to be a sensitive indicator of the degree of dependence3. We have used this method to follow the time courses of the onset and reversal of dependence in various conditions of exposure to opiates.
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CHENEY, D., GOLDSTEIN, A. Tolerance to Opioid Narcotics: Time Course and Reversibility of Physical Dependence in Mice. Nature 232, 477–478 (1971). https://doi.org/10.1038/232477a0
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DOI: https://doi.org/10.1038/232477a0
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