Abstract
THE discovery of Epstein and Barr1 of an antigenically and biologically unique herpes-like virus (EBV) in cultured cells derived from Burkitt's lymphoma aroused much speculation regarding the possible aetiological role of this agent in human lymphoproliferative diseases. Serological and clinical data provided strong evidence for the causal relationship between EBV and infectious mononucleosis2. The case for the possible association of EBV with Burkitt's lymphoma (BL) and nasopharyngeal carcinoma (NPC) rests mainly on the observation that patients with these diseases have significantly higher EBV antibody titres than matched controls from the same region3. Similar findings, however, were also reported in patients with sarcoidosis4 and systemic lupus erythematosus5.
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GERBER, P., HOYER, B. Induction of Cellular DNA Synthesis in Human Leucocytes by Epstein–Barr Virus. Nature 231, 46–47 (1971). https://doi.org/10.1038/231046a0
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DOI: https://doi.org/10.1038/231046a0
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