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Biochemical Research in Schizophrenia

Nature volume 231, pages 22–28 (1971)Cite this article

Abstract

Schizophrenia is still a loosely defined and little understood group of diseases. But a great deal of information is accumulating about the biochemical abnormalities which might be characteristic of so-called schizophrenics.

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References

  1. Kallman, F. J., in American Handbook of Psychiatry (edit. by Arieti, S.), 1, 175 (Basic Books, New York, 1959).

    Google Scholar 

  2. Essen-Möller, E., Acta Psychiat. Scand., 39, 65 (1963).

    Article  Google Scholar 

  3. Tienari, P., Acta Psychiat. Scand., 39, Suppl. 171 (1963).

  4. Kringlen, E., Acta Psychiat. Scand., 40, Suppl. 180, 313 (1965).

    Google Scholar 

  5. Kringlen, E., Psychiatry, 29, 172 (1966).

    Article  CAS  PubMed  Google Scholar 

  6. Heston, L. L., Brit. J. Psychiat., 112, 819 (1966).

    Article  CAS  PubMed  Google Scholar 

  7. Weil-Malherbe, H., Adv. Enzymol., 29, 479 (1967).

    CAS  PubMed  Google Scholar 

  8. Rosenbaum, C., J. Nerv. Ment. Dis., 146, 103 (1968).

    Article  CAS  PubMed  Google Scholar 

  9. Huxley, J., Mayr, E., Osmond, H., and Hoffer, A., Nature, 204, 220 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Kaplan, A. R., Nature, 210, 870 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Baldessarini, R. J., and Snyder, S. H., Nature, 206, 1111 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Moran, P. A. P., Nature, 206, 1113 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Osmond, H., and Smythies, J., J. Ment. Sci., 98, 309 (1952).

    Article  CAS  PubMed  Google Scholar 

  14. Harley-Mason, J., J. Ment. Sci., 98, 313 (1952).

    Google Scholar 

  15. Pollin, W., Cardon, P. V., and Kety, S. S., Science, 133, 104 (1961).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Park, L. C., Baldessarini, R. J., and Kety, S. S., Arch. Gen. Psychiat., 12, 346 (1965).

    Article  CAS  PubMed  Google Scholar 

  17. Alexander, F., Curtis, G. C., Sprince, H., and Crosley, A. P., J. Nerv. Ment. Dis., 137, 135 (1963).

    Article  CAS  PubMed  Google Scholar 

  18. Brune, G. C., and Himwich, H. E., J. Nerv. Ment. Dis., 134, 447 (1962).

    Article  CAS  PubMed  Google Scholar 

  19. Haydu, G. G., Dhrymiotis, A., Korenyi, C., and Goldschmidt, L., Amer. J. Psychiat., 122, 560 (1965).

    Article  CAS  PubMed  Google Scholar 

  20. Brune, G. C., and Himwich, H. E., in Recent Advances in Biological Psychiatry, 5, 144 (Plenum, 1963).

    Google Scholar 

  21. Sprince, H., in Amines and Schizophrenia (edit. by Himwich, H. E., Kety, S. S., and Smythies, J. R.) (Pergamon, 1967).

    Google Scholar 

  22. Hoffer, A., Osmond, H., Callbeck, M. J., and Kahan, I., J. clin. Exp. Psychopathol., 18, 131 (1957).

    CAS  PubMed  Google Scholar 

  23. Denson, R., Dis. Nerv. Syst., 23, 1 (1962).

    Google Scholar 

  24. Greenberg, D. M., Adv. Enzymol., 25, 395 (1963).

    Google Scholar 

  25. Friedhoff, A. J., and van Winkle, E., Nature, 194, 897 (1962).

    Article  ADS  CAS  Google Scholar 

  26. Boulton, A. A., and Felton, C., Nature, 211, 1404 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Takesada, M., Kakimoto, Y., Sano, I., and Kaneko, Z., Nature, 199, 203 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Takesda, M., Miyamoto, E., Kakimoto, Y., Sano, I., and Kaneko, Z., Nature, 207, 1199 (1965).

    Article  ADS  Google Scholar 

  29. Von Studnitz, W., and Nyman, G. E., Acta Psychiat. Scand., 41, 117 (1965).

    Article  CAS  PubMed  Google Scholar 

  30. Faurbye, A., and Pind, K., Acta Psychiat. Scand., 40, 240 (1964).

    Article  CAS  PubMed  Google Scholar 

  31. Pind, K., and Faurbye, A., Acta Psychiat. Scand., 42, 246 (1966).

    Article  CAS  PubMed  Google Scholar 

  32. Williams, C. H., Gibson, J. G., and McCormick, W. O., Nature, 211, 1195 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  33. Perry, T. L., Hansen, S., and MacIntyre, L., Nature, 202, 519 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  34. Nishimura, T., and Gjessing, L. R., Nature, 206, 963 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  35. Sen, N. P., and McGeer, P. L., Biochem. Biophys. Res. Commun., 14, 227 (1964).

    Article  CAS  PubMed  Google Scholar 

  36. Jones, R. L., Bory, P., Brown, W. T., and McGeer, P. L., Canad. J. Biochem., 47, 185 (1969).

    Article  CAS  Google Scholar 

  37. Perry, T. L., Hansen, S., MacDougall, L., and Schwarz, C. J., Nature, 212, 146 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  38. Perry, T. L., Hansen, S., and MacDougall, L., Nature, 214, 484 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  39. Kuehl, F. A., Hichens, M., Ormond, R. E., Meisinger, M. A. P., Gale, P. A., Cirillo, V. J., and Brink, N. G., Nature, 203, 154 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  40. Kuehl, F. A., Ormond, R. E., and Vandenheuvel, W. J. A., Nature, 211, 606 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  41. Bell, C. E., and Somerville, A. R., Nature, 211, 1405 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Boulton, A. A., and Felton, C., Lancet, ii, 964 (1966).

  43. Barbeau, A., De Groot, J. A., Joly, J. G., Raymond-Tremblay, D., and Donaldson, J., Rev. Canad. Biol., 22, 469 (1963).

    CAS  PubMed  Google Scholar 

  44. Boulton, A. A., Pollitt, R. J., and Majer, J. R., Nature, 215, 132 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  45. Rinne, U. K., and Sonninen, V., Nature, 216, 489 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  46. Creveling, C. R., and Daly, J. W., Nature, 216, 190 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  47. Closs, K., Wad, N., and Ose, E., Nature, 214, 483 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  48. Steinberg, H. R., and Robinson, J., Nature, 217, 1054 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  49. Bourdillon, R. E., Clark, C. A., Ridges, A. P., Sheppard, P. M., Harper, P., and Leslie, S. A., Nature, 208, 453 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  50. Boulton, A. A., Second Intern. Cong. Neurogenetics and Neuroophthalmology, Montreal (1967), Excerpta Medica, No. 154, 35.

    Google Scholar 

  51. Boulton, A. A., in Methods of Biochemical Analysis (edit. by Glick, D.), 16, 327 (Interscience 1969).

    Google Scholar 

  52. Friedhoff, A. J., and van Winkle, E., Nature, 199, 1271 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  53. Faurbye, A., and Pind, K., Nature, 215, 1387 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  54. Wagner, A. F., Cirillo, V. J., Meisinger, M. A. P., Ormond, R. E., Kuehl, F. A., and Brink, N. G., Nature, 211, 604 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  55. Sargent, T. W., Israelstam, D. M., Shulgin, A. T., Landaw, S. A., and Finlay, N. N., Biochem. Biophys. Res. Commun., 29, 126 (1967).

    Article  CAS  PubMed  Google Scholar 

  56. de Jong, H., Proc. Roy. Acad. Sci., Amsterdam, 34, II, 576 (1931).

    CAS  Google Scholar 

  57. Noteboom, L., Proc. Roy. Acad. Sci., Amsterdam, 37, II, 562 (1934).

    CAS  Google Scholar 

  58. Ernst, A. M., Nature, 193, 178 (1962).

    Article  ADS  CAS  PubMed  Google Scholar 

  59. Vogel, W. H., and Horwitt, M. K., Psychopharmacologia, 11, 265 (1967).

    Article  CAS  PubMed  Google Scholar 

  60. Smythies, J. R., and Sykes, E. A., Psychopharmacologia, 8, 324 (1966).

    Article  CAS  PubMed  Google Scholar 

  61. Bergen, J. R., Trans. NY Acad. Sci., 28, 40 (1965).

    Article  CAS  Google Scholar 

  62. Proctor, C. D., Cho, J. B., Potts, J. L., Ashley, L. G., Douglas, J. G., Amoroso, C. P., McGriff, J. E., and Eaton, H. E., Arch. Intern. Pharmacodyn., 172, 95 (1968).

    CAS  Google Scholar 

  63. Proctor, C. D., Cho, J. B., Ashley, L. G., Potts, J. L., Eaton, H. E., McGriff, J. E., Douglas, J. G., and Amoroso, C. P., Arch. Intern. Pharmacodyn., 172, 106 (1968).

    CAS  Google Scholar 

  64. Dear, E. M. A., and Malcolm, J. C., Intern. J. Neuropharmacol., 6, 529 (1967).

    Article  CAS  Google Scholar 

  65. Takeo, Y., and Himwich, H. E., Science, 150, 1309 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  66. Brown, M. L., Lang, W. J., and Gershon, S., Arch. Intern. Pharmacodyn., 158, 439 (1965).

    CAS  Google Scholar 

  67. Barbeau, A., Tetreault, L., Oliva, L., Morazain, L., and Cardin, L., Nature, 209, 719 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  68. Barbeau, A., Singh, P., Gaudreau, P., and Joubert, M., Rev. Canad. Biol., 24, 229 (1965).

    CAS  PubMed  Google Scholar 

  69. Barbeau, A., Lescop, J., Duplessis, P., and Elie, R., Experientia, 23, 1 (1967).

    Article  Google Scholar 

  70. Hollister, L. E., and Friedhoff, A. J., Nature, 210, 1377 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  71. Shulgin, A. T., Sargent, T., and Naranjo, C., Nature, 212, 1606 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  72. Axelrod, J., Biochim. Biophys. Acta, 85, 247 (1964).

    CAS  PubMed  Google Scholar 

  73. LaBrosse, E. H., Mann, J. D., and Kety, S. S., J. Psychiat. Res., 1, 68 (1961).

    Article  CAS  PubMed  Google Scholar 

  74. Resnick, O., and Elmadjian, F., Amer. J. Physiol., 187, 626 (1956).

    Google Scholar 

  75. Resnick, O., and Freeman, H., Arch. Gen. Psychiat., 6, 388 (1962).

    Article  CAS  PubMed  Google Scholar 

  76. Pollin, W., and Goldin, S., J. Psychiat. Res., 1, 50 (1961).

    Article  CAS  PubMed  Google Scholar 

  77. Cardon, P. V., and Mueller, A. S., J. Psychiat. Res., 2, 11 (1964).

    Article  PubMed  Google Scholar 

  78. Cardon, P. V., Sokoloff, L., Vates, T. S., and Kety, S. S., J. Psychiat. Res., 1, 37 (1961).

    Article  CAS  PubMed  Google Scholar 

  79. Shulgin, A. T., Sargent, T., and Narenjo, C., Nature, 221, 537 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  80. Senoh, S., Creveling, C. R., Udenfriend, S., and Witkop, B., J. Amer. Chem. Soc., 81, 6236 (1959).

    Article  CAS  Google Scholar 

  81. Benassi, C. A., Benassi, P., Allegri, G., and Ballarin, D., J. Neurochem., 7, 264 (1961).

    Article  CAS  Google Scholar 

  82. Price, J. M., Brown, R. R., and Peters, H. A., Neurology, 9, 456 (1959).

    Article  CAS  PubMed  Google Scholar 

  83. Sprince, H., Ann. NY Acad. Sci., 96, 399 (1962).

    Article  ADS  CAS  PubMed  Google Scholar 

  84. Pauling, L., Science, 160, 265 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  85. HaszáK, I., and Durkó, I., Acta Biochimica Polonica, 11, 389 (1964).

    Google Scholar 

  86. Fischer, E., Vazquez, F. A., Fernández, T. A., and Liskowski, L., Lancet, i, 890 (1961).

  87. Brune, G. G., and Himwich, H. E., Arch. Gen. Psychiat., 6, 324 (1962).

    Article  Google Scholar 

  88. Berlet, H. H., Pscheidt, G. R., Spaide, J. K., and Himwich, H. E., Nature, 203, 1198 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  89. Pscheidt, G. R., Berlet, H. H., Spaide, J., and Himwich, H. E., Clin. Chim. Acta, 13, 228 (1966).

    Article  CAS  PubMed  Google Scholar 

  90. Maire, F. W., and Hixon, A. C., Intern. J. Neuropsychiat., 2, 135 (1966).

    CAS  Google Scholar 

  91. Gessner, P. K., Khairallah, P. A., Mclsaac, W. M., and Page, I. H., J. Pharm. Exp. Therap., 130, 126 (1960).

    CAS  Google Scholar 

  92. Fischer, R., Nature, 220, 411 (1968).

    Article  ADS  Google Scholar 

  93. Bumpus, F. M., and Page, I. H., J. Biol Chem., 212, 111 (1955).

    CAS  PubMed  Google Scholar 

  94. Fischer, E., Fernandez-Lagravere, T. A., Vázquez, A. J., and DiStefano, A. O., J. Nerv. Ment. Dis., 133, 441 (1961).

    Article  CAS  PubMed  Google Scholar 

  95. Schneider, K., Fortschr. Neurol. Psych., 25, 487 (1957).

    CAS  Google Scholar 

  96. Spatz, H., Pren. Méd. Argent., 54, 2116 (1967).

    CAS  Google Scholar 

  97. Fischer, E., and Spatz, H., Arch. Psychiat. Z. Neurol., 211, 241 (1968).

    Article  CAS  Google Scholar 

  98. Franzen, F., and Gross, H., Nature, 206, 1052 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  99. Gross, H., and Franzen, F., Biochem. Z., 340, 403 (1964).

    CAS  PubMed  Google Scholar 

  100. Perry, T. L., Shaw, K. N. F., Walker, D., and Redlich, D., Pediatrics, 30, 576 (1962).

    CAS  Google Scholar 

  101. Rodnight, R., Biochem. J., 64, 621 (1956).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Seigel, M., J. Psychiat. Res., 3, 205 (1965).

    Article  Google Scholar 

  103. Runge, T. M., Lara, F. Y., Nawasa-Thurman, M. J., Keyes, J. W., and Hoerster, S. H., J. Nerv. Ment. Dis., 142, 473 (1966).

    Article  Google Scholar 

  104. Brune, G. G., Hohl, H. H., and Himwich, H. E., J. Neuropsychiat., 5, 14 (1963).

    Google Scholar 

  105. Axelrod, J., Science, 134, 343 (1961).

    Article  ADS  CAS  PubMed  Google Scholar 

  106. Axelrod, J., J. Pharmacol. Exp. Therap., 138, 28 (1962).

    CAS  Google Scholar 

  107. Sanders, E., and Bush, M. T., J. Pharmacol. Exp. Therap., 158, 340 (1967).

    CAS  Google Scholar 

  108. Gessner, P. K., and Page, I., Amer. J. Physiol., 203, 167 (1962).

    Article  CAS  Google Scholar 

  109. Holmstedt, B., in Amines and Schizophrenia (edit. by Himwich, H. E., Kety, S. S., and Smythies, J. R.), 151 (Pergamon, Oxford, 1967).

    Book  Google Scholar 

  110. Spaide, J., Tanimukai, H., Ginther, R., Bueno, J., and Himwich, H. E., Life Sci., 6, 551 (1967).

    Article  CAS  PubMed  Google Scholar 

  111. Bindler, E., Sanghvi, I., and Gershon, S., Arch. Intern. Pharmacodyn., 176, 1 (1968).

    CAS  Google Scholar 

  112. Tanimukai, H., Ginther, R., Spaide, J., Bueno, J. R., and Himwich, H. E., Life Sci., 6, 1697 (1957).

    Article  Google Scholar 

  113. Tanimukai, H., Ginther, R., Spaide, J., and Himwich, H. E., Nature, 216, 490 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  114. Faurhye, A., and Pind, K., Nature, 220, 489 (1968).

    Article  ADS  Google Scholar 

  115. Faurbye, A., Comp. Psychiat., 9, 155 (1968).

    Article  CAS  Google Scholar 

  116. Kety, S. S., in Amines and Schizophrenia (edit. by Himwich, H. E., Kety, S. S., and Smythies, J. R.), 272 (Pergamon, Oxford, 1967).

    Google Scholar 

  117. Randrup, A., Munkvad, I., and Udsen, P., Acta Pharmacol. Toxicol., 20, 145 (1963).

    Article  CAS  Google Scholar 

  118. Munkvad, I., and Randrup, A., Acta Psychiat. Scand., 42, Suppl. 191, 178 (1966).

    Article  Google Scholar 

  119. Randrup, A., and Munkvad, I., Acta Psychiat. Scand., 42, Suppl. 191, 193 (1966).

    Article  Google Scholar 

  120. Quinton, R., and Halliwell, G., Nature, 200, 178 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  121. Fog, R. L., Randrup, A., and Pakkenberg, H., Psychopharmacologia, 11, 179 (1967).

    Article  CAS  PubMed  Google Scholar 

  122. Randrup, A., and Scheel-Kruger, J., J. Pharm. Pharmacol., 18, 752 (1966).

    Article  CAS  PubMed  Google Scholar 

  123. Randrup, A., and Jonas, W., J. Pharm. Pharmacol., 19, 483 (1967).

    Article  CAS  PubMed  Google Scholar 

  124. Randrup, A., and Munkvad, I., Nature, 211, 540 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  125. Scheel-Krüger, J., and Randrup, A., Life Sci., 6, 1389 (1967).

    Article  PubMed  Google Scholar 

  126. Sourkes, T. L., in Neurochemistry, second ed. (edit. by Elliott, K. A. C., Page, I. H., and Quastel, J. H.) (Thomas, Springfield, 1962).

    Google Scholar 

  127. Cotzias, G. C., and Papavasiliou, P. S., in Second Intern. Cong. Neurogenetics and Neuro-ophthalmology, Montreal, 1967, Excerpta Medica, No. 154, 30 (1967).

    Google Scholar 

  128. Fuller, R. N., and Shuman, J. B., Nature, 221, 639 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  129. Sohler, A., Renz, R. H., Smith, S., and Kaufman, J., Intern. J. Neuropsychiat., 3, 327 (1967).

    CAS  Google Scholar 

  130. Greiner, A. C., Dis. Nerv. Syst., 29, 14 (1968).

    Google Scholar 

  131. Greiner, A. C., and Nicolson, G. A., Lancet, ii, 1165 (1965).

  132. Nicholson, G. A., Greiner, A. C., McFarlane, W. J. G., and Baker, R. A., Lancet, i, 344 (1966).

  133. Huszák, I., and Durkó, I., Proc. Fourth World Cong. Psychiat., Madrid, 1966, Excerpta Med., No. 150, 2931 (1966).

    Google Scholar 

  134. Irvine, D. G., J. Neuropsychiat., 2, 292 (1961).

    CAS  PubMed  Google Scholar 

  135. O'Reilly, P. O., Ernest, M., and Hughes, G., Brit. J. Psychiat., 111, 741 (1965).

    Article  CAS  PubMed  Google Scholar 

  136. O'Reilly, P. O., Hughes, G., Russel, S., and Ernest, M., Dis. Nerv. Syst., 26, 562 (1965).

    CAS  PubMed  Google Scholar 

  137. O'Brien, D., and Jensen, C. B., Clin. Sci., 24, 179 (1963).

    Google Scholar 

  138. Hunter, R., and Mathews, D. M., Lancet, ii, 738 (1965).

  139. Nature, 221, 410 (1969).

  140. Reynolds, E. H., Brit. J. Psychiat., 113, 911 (1967).

    Article  CAS  PubMed  Google Scholar 

  141. Reynolds, E. H., Chanadrin, I., Milner, G., and Mathews, D. M., Epilepsia, 1, 261 (1966).

    Article  Google Scholar 

  142. Kety, S. S., Science, 129, 1528 (1959).

    Article  ADS  CAS  PubMed  Google Scholar 

  143. Beckett, P. G. A., Senf, R., Frohman, C. E., Tourney, G., and Gottlieb, J. S., Amer. J. Psychiat., 118, 959 (1962).

    Article  Google Scholar 

  144. Frohman, C. E., Czajkowski, N. P., Luby, E. D., Gottlieb, J. S., and Senf, R., Arch. Gen. Psychiat., 2, 263 (1960).

    Article  CAS  Google Scholar 

  145. Frohman, C., Luby, E. D., Tourney, G., Beckett, P. G. S., and Gottlieb, J. S., Amer. J. Psychiat., 5, 401 (1960).

    Article  Google Scholar 

  146. Frohman, C. E., Goodman, M., Beckett, P. G. S., Latham, L. K., Senf, R., and Gottlieb, J. S., Ann. NY Acad. Sci., 96, 438 (1962).

    Article  ADS  CAS  PubMed  Google Scholar 

  147. Latham, K., Warner, K., Frohman, C., and Gottlieb, J., Fed. Proc., 21, 415 (1962).

    Google Scholar 

  148. Buhler, D. R., and Ihler, G. S., J. Lab. Clin. Med., 62, 306 (1963).

    CAS  PubMed  Google Scholar 

  149. Mangoni, A., Balazs, A., and Coppen, A. J., Brit. J. Psychiat., 109, 231 (1963).

    Article  CAS  Google Scholar 

  150. Brown, F. C., Arch. Gen. Psychiat., 10, 409 (1964).

    Article  CAS  PubMed  Google Scholar 

  151. Ryan, J. W., Brown, J. D., and Durell, J., Science, 151, 1408 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  152. Walaas, O., Lingjaerde, O., Loken, E., and Hundevadt, E., Scand. J. Clin. Lab. Invest., 6, 245 (1954).

    Article  CAS  PubMed  Google Scholar 

  153. Walaas, O., Walaas, E., Søvik, O., Alertsen, A. R., and Lindjaerde, O., Conf. Neurol., 25, 175 (1965).

    Article  CAS  Google Scholar 

  154. Fessel, W. J., Arch. Gen. Psychiat., 6, 132 (1962).

    Article  CAS  PubMed  Google Scholar 

  155. Fessel, W. J., Arch. Gen. Psychiat., 8, 614 (1963).

    Article  CAS  PubMed  Google Scholar 

  156. Gammack, D. B., and Hector, R. I., Clin. Sci., 28, 469 (1965).

    CAS  PubMed  Google Scholar 

  157. Fessel, W. J., Kurland, H. D., and Cutler, R. P., Arch. Intern. Med., 113, 669 (1964).

    Article  CAS  PubMed  Google Scholar 

  158. Fessel, W. J., Arch. Gen. Psychiat., 7, 427 (1962).

    Article  Google Scholar 

  159. Seal, U. S., and Eist, H., Clin. Chem., 12, 709 (1966).

    CAS  PubMed  Google Scholar 

  160. Seal, U. S., and Swaim, W. R., Clin. Chem., 14, 368 (1968).

    CAS  PubMed  Google Scholar 

  161. Seal, U. S., Swaim, W. R., and Eist, H., Clin. Chem., 13, 160 (1967).

    CAS  PubMed  Google Scholar 

  162. Fessel, W. J., Hirata-Hibi, M., and Shapiro, I. M., J. Psychiat. Res., 3, 275 (1965).

    Article  CAS  PubMed  Google Scholar 

  163. Vanderkamp, H., and Daly, R., J. Neuropsychiat., 4, 4 (1968).

    CAS  Google Scholar 

  164. Hollister, L. L., and Kosek, J. C., Intern. J. Neuropsychiat., 1, 559 (1965).

    CAS  Google Scholar 

  165. Fessel, W. J., and Hirata-Hibi, M., Arch. Gen. Psychiat., 9, 601 (1963).

    Article  CAS  PubMed  Google Scholar 

  166. Fessel, W. J., and Grunbaum, B. W., Ann. Intern. Med., 54, 1134 (1961).

    Article  CAS  PubMed  Google Scholar 

  167. Solomon, G. F., Moos, R. H., Fessel, W. J., and Morgan, E. E., Intern. J. Neuropsychiat., 2, 20 (1966).

    CAS  Google Scholar 

  168. Bergen, J. R., Pennell, R. B., Freeman, H., and Hoagland, H., Amer. Med. Assoc. Arch. Neurol., 2, 146 (1960).

    Article  CAS  Google Scholar 

  169. Bishop, M. P., Dis. Nerv. Syst., 21, 1 (1960).

    Google Scholar 

  170. Hoffer, A., and Osmond, H., Acta Psychiat. Scand., 39, 335 (1963).

    Article  CAS  PubMed  Google Scholar 

  171. Throne, M. L., Gowdey, C. W., and Lovegrove, T. D., J. Nerv. Ment. Dis., 142, 248 (1966).

    Article  CAS  PubMed  Google Scholar 

  172. Stewart, C. N., and Irvine, D. G., Dis. Nerv. Syst., 23, 456 (1962).

    CAS  PubMed  Google Scholar 

  173. Lovegrove, T. D., and Nicholls, D. M., J. Nerv. Ment. Dis., 141, 195 (1965).

    Article  Google Scholar 

  174. Sapira, J. D., Arch. Gen. Psychiat., 10, 196 (1964).

    Article  CAS  PubMed  Google Scholar 

  175. Jensen, K., Clausen, J., and Osterman, E., Acta Psychiat. Scand., 40, 280 (1964).

    Article  CAS  PubMed  Google Scholar 

  176. Heath, R. G., Martens, S., Leach, B. E., Cohen, M., and Fengley, C. A., Amer. J. Psychiat., 114, 917 (1958).

    Article  CAS  PubMed  Google Scholar 

  177. Heath, R. G., Martens, S., Cohen, M., and Angel, C., Amer. J. Psychiat., 114, 14 (1957).

    Article  CAS  PubMed  Google Scholar 

  178. Heath, R. G., Intern. Rev. Neurobiol., 1, 300 (1959).

    Google Scholar 

  179. Heath, R. G., and Leach, B. E., Ann. NY Acad. Sci., 96, 425 (1962).

    Article  ADS  CAS  PubMed  Google Scholar 

  180. Leach, B. E., Byers, L. W., and Heath, R. G., Serological Fractions in Schizophrenia (edit. by Heath, R. G.), (Harper and Row, New York, 1963).

    Google Scholar 

  181. Melander, B., and Martens, S., Dis. Nerv. Syst., 19, 478 (1958).

    CAS  PubMed  Google Scholar 

  182. Nelson, J. W., Daniels, E. G., Mann, K. M., and Hinman, J. W., Serological Fractions in Schizophrenia (edit. by Heath, R. G.), 43 (Harper and Row, New York, 1963).

    Google Scholar 

  183. Winter, C. A., Flataker, L., Boyer, W. P., Smith, E. V. C., and Sanders, B. E., in Chemical Pathology of Nervous System (edit. by Folch-Pi, J.), 64 (Pergamon, New York, 1961).

    Google Scholar 

  184. Bergen, J. R., Pennell, R. B., Saravis, C. A., and Hoagland, H., in Serological Fractions in Schizophrenia (edit. by Heath, R. G.), 67 (Harper and Row, New York, 1963).

    Google Scholar 

  185. Bergen, J. R., Gray, F. W., Pennell, R. B., Freeman, H., and Hoagland, N., Arch. Gen. Psychiat., 12, 80 (1965).

    Article  CAS  PubMed  Google Scholar 

  186. Mekler, L. B., Laptera, N. N., Lozovski, D. V., and Balezina, T. I., Dokl. Akad. Nauk. SSSR, 130, 148 (1960).

    Google Scholar 

  187. Heath, R. G., and Krupp, I. M., Arch. Gen. Psychiat., 16, 3 (1967).

    Google Scholar 

  188. Heath, R. G., Krupp, I. M., Byers, L. W., and Liljekvist, J. I., Arch. Gen. Psychiat., 16, 10 (1967).

    Article  CAS  PubMed  Google Scholar 

  189. Heath, R. G., Krupp, I. M., Byers, L. W., and Liljekvist, J. I., Arch. Gen. Psychiat., 16, 24 (1967).

    Article  CAS  PubMed  Google Scholar 

  190. Heath, R. G., and Krupp, I. M., Amer. J. Psychiat., 124, 1019 (1968).

    Article  Google Scholar 

  191. Lehman, H. E., Amer. J. Psychiat., 124, 1024 (1968).

    Google Scholar 

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  1. Psychiatric Research Unit, University Hospital, Saskatoon, Saskatchewan

    ALAN A. BOULTON

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BOULTON, A. Biochemical Research in Schizophrenia. Nature 231, 22–28 (1971). https://doi.org/10.1038/231022a0

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