Abstract
THE addition of lithium ions to the fluid bathing Aplysia ganglion cells results in presynaptic electrical changes consistent with decreased acetylcholine (ACh) release1. To ascertain directly the effect of lithium on ACh release from mammalian brain, Bowers and Rozitis2 injected rats with lithium chloride and measured the release of endogenous ACh from electrically stimulated cortical brain slices, but did not find a significant difference in the electrically stimulated release of ACh in slices prepared from animals injected with sodium chloride compared with lithium chloride. They concluded, therefore, that lithium ions do not decrease ACh release in mammalian brain. But they allowed the possibility that certain more physiological forms of ACh release in the brain might be influenced by lithium.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Waziri, R., Life Sci., 7, 865 (1968).
Bowers, jun., M. B., and Rozitis, A., J. Pharmac. Pharmacol., 22, 647 (1970).
MacIntosh, F. C., and Oborin, P. E., Nineteenth Cong. Intern. Physiol., 580 (1953).
MacIntosh, F. C., and Perry, W. L. M., Methods Med. Res., 3, 78 (1950).
Mitchell, J. F., J. Physiol., 165, 98 (1963).
Hodgkin, A. L., and Katz, B., J. Physiol., 108, 37 (1949).
Keynes, R. D., and Swan, R. C., J. Physiol., 147, 626 (1959).
Ritchie, J. M., and Straub, R. W., J. Physiol., 136, 80 (1957).
Fatt, P., J. Physiol., 111, 408 (1950).
Armett, C. J., and Ritchie, J. M., J. Physiol., 165, 130 (1963).
Klingman, J. D., Life Sci., 5, 365 (1966).
Pappano, A. J., and Volle, R. L., J. Pharmacol. Exp. Therap., 157, 346 (1967).
Araki, T., Ito, M., Kostyuk, P. G., Oscarsson, O., and Oshima, T., Proc. Roy. Soc., B, 162, 319 (1965).
Carmeliet, E. E., J. Gen. Physiol., 47, 501 (1964).
Birks, R. I., Canad. J. Biochem. Physiol., 3, 2573 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BJEGOVIĆ, M., RANDIĆ, M. Effect of Lithium Ions on the Release of Acetylcholine from the Cerebral Cortex. Nature 230, 587–588 (1971). https://doi.org/10.1038/230587a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/230587a0
This article is cited by
-
Effectiveness of Zinc in Modulating Lithium Induced Biochemical and Behavioral Changes in Rat Brain
Cellular and Molecular Neurobiology (2007)
-
Lithium administration antagonizes cholinergic behavioral effects in rodents
Psychopharmacology (1979)
-
Effect of lithium carbonate on memory processes of bipolar affectively ill patients
Psychopharmacology (1979)
-
Increased calcium and magnesium excretion induced by lithium carbonate
Psychopharmacologia (1972)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
