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Identification of Prostaglandin F2α released by Distension of Guinea-pig Uterus in vitro

Nature volume 230, pages 526–528 (1971)Cite this article

Abstract

DISTENSION of the guinea-pig uterus early in the oestrous cycle significantly shortens the cycle1, as the size of the corpora lutea shows. Furthermore, distension of one uterine horn affects only the corpora lutea of the ipsilateral ovary2. Thus there seems to be a local utero-ovarian relationship. Total hysterectomy3, severance of the vascular tissue between the ovary and uterus4,5, or destruction of the endometrium6 significantly lengthens the oestrous cycle. Hemi-hysterectomy affects only the ipsilateral corpora lutea7. Transplantation of the uterus or of the endometrium alone maintains slightly extended oestrous cycles8. A nervous mechanism cannot account for all these observations, and it has been suggested that a luteolytic substance is released from the endometrium and reaches the ovary, possibly through the blood or lymphatic vessels, causing the corpora lutea to degenerate.

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Authors and Affiliations

  1. Department of Pharmacology, University of Edinburg, 1 George Square, Edinburgh, EH8 9JZ

    N. L. POYSER, E. W. HORTON, C. J. THOMPSON & M. Los

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  1. N. L. POYSER
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  2. E. W. HORTON
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  3. C. J. THOMPSON
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  4. M. Los
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POYSER, N., HORTON, E., THOMPSON, C. et al. Identification of Prostaglandin F2α released by Distension of Guinea-pig Uterus in vitro. Nature 230, 526–528 (1971). https://doi.org/10.1038/230526a0

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