Abstract
CELL lines derived from neoplastic tissue differ from those from normal adult tissue1 in their capacity to survive and grow in the cheek pouch of a hamster treated with cortisone, and this difference is now the basis of a test for potential malignancy. We have found a simple and rapid alternative in the use of hamsters treated with antilymphocyte serum (ALS) and this may be valuable in the screening for tumorigenicity in human diploid cell strains used in the production of virus vaccines2,3. ALS is an effective suppressor of immune responses to skin allografts4, of tumour induction by oncogenic viruses5 and of the development of metastases of allogeneic tumour grafts6. It is also known that tumours are formed in ALS-treated weanling mice after subcutaneous inoculation of cultured human tumour cells7,8. It was this that suggested that ALS may provide an improved alternative to standard methods of host conditioning for tumour transplantation.
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WALLACE, R., VASINGTON, P. & PETRICCIANI, J. Heterotransplantation of Cultured Cell Lines in Newborn Hamsters treated with Antilymphocyte Serum. Nature 230, 454–455 (1971). https://doi.org/10.1038/230454a0
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DOI: https://doi.org/10.1038/230454a0
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