Abstract
SEVERAL studies have implicated the delayed hypersensitivity reaction in the body's response to cancer. Hughes and Lytton found that one cancer patient in four demonstrated a delayed cutaneous hypersensitivity response to an antigen consisting of small cytoplasmic particles obtained after ultrasonic disruption of their tumours1. There have been several studies of the ability of cancer patients to react to the antigens commonly used for delayed cutaneous hypersensitivity testing2–9; in general, while responsiveness was affected little, if at all, in patients with early cancer, it decreased as disease and debility progressed. The ability to develop contact sensitivity to dinitrochloro-benzene or dinitrofluoro-benzene is decreased in cancer patients, particularly those with advanced disease10,11. Such sensitivity has been shown to be related to prognosis12.
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WOLBERG, W., GOELZER, M. In vitro Assay of Cell Mediated Immunity in Human Cancer: Definition of Leukocyte Migration Inhibitory Factor. Nature 229, 632–634 (1971). https://doi.org/10.1038/229632a0
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DOI: https://doi.org/10.1038/229632a0
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