Abstract
IT is well known that 5-hydroxy-L-tryptophan (5-HTP) occurs in low concentration in mammalian brain serving as the precursor of 5-hydroxytryptamine (5-HT, serotonin). Furthermore, 5-HTP but not 5-HT can pass readily across the blood-brain barrier so that the physiological effects associated with an increase of 5-HT in the brain may be induced in rats and dogs by the interperitoneal injection of 5-HTP1,2. A recent report indicated that 5-HTP produced improvement in a patient suffering from the Parkinson-like symptoms of chronic manganese poisoning after treatment with L-3,4-dihydroxy-phenylalanine (L-dopa) had aggravated his condition3.
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References
Udenfriend, S., Titus, E., Weissbach, H., and Peterson, R. E., J. Biol. Chem., 219, 335 (1956).
Udenfriend, S., Weissbach, H., and Bogdanski, D. F., J. Biol. Chem., 224, 803 (1957).
Mena, I., Court, J., Fuenzalida, S., Paprasiliou, P. S., and Cotzias, G. C., New Engl. J. Med., 282, 5 (1970).
Bell, E. A., and Fellows, L. E., Nature, 210, 529 (1966).
Irvine, F. R., Woody Plants of Ghana, 309 (Oxford Univ. Press, 1961).
Fellows, L. E., and Bell, E. A., Phytochemistry (in the press).
Calne, D. B., and Sandler, M., Nature, 226, 21 (1970).
Torquati, T., Arch. Farmacol. Sper., 15, 308 (1913).
Miller, E. R., J. Biol Chem., 44, 481 (1920).
Damodaran, M., and Ramaswamy, R., Biochem. J., 31, 2149 (1937).
Janzen, D. H., Evolution, 23, 1 (1969).
Janzen, D. H., Ecology (in the press).
Standley, P. C., Cont. US Nat. Herb., 23, 171 (1922).
Meister, A., Biochemistry of the Amino Acids, 1, 233 (Academic Press, New York and London, 1965).
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BELL, E., JANZEN, D. Medical and Ecological Considerations of L-Dopa and 5-HTP in Seeds. Nature 229, 136–137 (1971). https://doi.org/10.1038/229136a0
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DOI: https://doi.org/10.1038/229136a0
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