Abstract
ONE of the many properties of prostaglandin E1 (PGE1) is that it inhibits the aggregation of blood platelets in plasma at µg/ml. platelet-rich plasma1–3, and of ADP-induced adhesiveness at the same low concentration1,2. Emmons et al.1 have also shown that platelet plug formation is prevented in vivo during infusion of PGE1. Because of this we decided to investigate the effect of PGE1 on clot retraction.
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References
Emmons, P. R., Hampton, J. R., Harrison, M. J. G., Honour, A. J., and Mitchell, J. R. A., Brit. Med. J., 2, 468 (1968).
Kloeze, J., Nobel Symp. Prostaglandins (edit. by Bergström, S. and Samuelsson, B.), 241 (Almquist and Wiksell, Stockholm, 1967).
Irion, E., and Blombäck, M., Scand. J. Clin. Lab. Invest., 24, 141 (1969).
Blombäck, B., and Blombäck, M., Arkiv för Kemi, 10, 415 (1956).
Solum, N. O., Scand. J. Clin. Lab. Invest., 18, 577 (1966).
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MÜRER, E. Biological Sciences: Effect of Prostaglandin on E1 on Clot Retraction. Nature 229, 112–113 (1971). https://doi.org/10.1038/229112a0
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DOI: https://doi.org/10.1038/229112a0
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