Abstract
GERMINAL centres develop early in the immune response, and although knowledge of these structures is far from complete, they are known to be intimately associated with the capacity to produce specific antibodies after antigenic stimulation1. The localization of antigen in these centres coincides with the appearance of specific serum antibody2, which is found in a close relationship to reticular cells in these areas3. It produces a characteristic dendritic intercellular pattern of immunofluorescent staining or autoradiography when isotopically labelled. This localization of antigen in germinal centres did not occur in rabbits rendered tolerant to haemocyanin or human serum albumin4, but injected immune complexes produced an identical pattern of localization of antigen in germinal centres in normal rat lymph nodes5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cottier, H., Odartchenko, N., Schindler, R., and Congdon, C. C., Germinal Centres in Immune Responses (Springer-Verlag, New York, 1967).
Hanna, M. G. jun., Francis, M. N., and Peters, L. C., Immunology, 15, 75 (1968).
Mitchell, J., and Abbott, A., Nature, 208, 500 (1965).
Humphrey, J. H., and Frank, M. M., Immunology, 13, 87 (1967).
Lang, P. G., and Ada, G. L., Immunology, 13, 523 (1967).
Brown, J. C., Schwab, J. H., and Holborow, E. J., Immunology, 19, 401 (1970).
Ford, N. L., and Gowans, J. L., Proc. Roy. Soc., B, 168, 244 (1967).
Levey, R. H., and Medawar, P. B., Ann. NY Acad. Sci., 129, 164 (1966).
Naor, D., and Sulitzeanu, D., Nature, 214, 687 (1967).
Ada, G. L., and Byrt, P., Nature, 222, 1291 (1969).
Warner, N. L., and Byrt, P., Nature, 226 942 (1970).
Sell, S., and Gell, P. G. H., J. Exp. Med., 122, 813 (1965).
Martin, W. J., and Miller, J. F. A. P., J. Exp. Med., 128, 855 (1968).
Henry, C., and Jerne, N. K., J. Exp. Med., 128, 133 (1968).
Uhr, J. W., and Baumann, J. B., J. Exp. Med., 113, 935 (1961).
Wigzell, H., J. Exp. Med., 124, 953 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BROWN, J., DE JESUS, D., HOLBOROW, E. et al. Lymphocyte-mediated Transport of Aggregated Human γ-Globulin into Germinal Centre Areas of Normal Mouse Spleen. Nature 228, 367–369 (1970). https://doi.org/10.1038/228367a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/228367a0
This article is cited by
-
B cell follicles and antigen encounters of the third kind
Nature Immunology (2010)
-
The who, how and where of antigen presentation to B cells
Nature Reviews Immunology (2009)
-
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
Nature Immunology (2007)
-
Holding antigen where B cells can find it
Nature Immunology (2007)
-
Origin of follicular dendritic cell in the chicken spleen
Cell and Tissue Research (2006)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
