Abstract
MANY tumour growth inhibiting substances have been studied in various tumour systems: aliphatic diamines, hydroxy-amines, aromatic bases with two terminal groups1, the synthetic polypeptides of lysine such as positively charged poly-DL-lysine2, polyornithine3, histones4, lysine-rich histone fractions5, DEAE-dextran6,7, polyethylenimine8,9, polyvinylamine bisulphate and polypropylenimine9. The synthetic double-stranded ribonucleic acid—a complex of polyinosinic acid and polycytidylic acid—(poly I.poly C), which is highly negatively charged, has also been demonstrated to inhibit the growth of several transplantable malignant murine tumours of known or unknown viral aetiology10–17. Some reports describe the protective action of poly I.poly C on non-viral diseases as well10,18. Certain polysaccharides isolated from lichens significantly inhibited the growth of implanted sarcoma-180 in mice and caused complete tumour regression in many cases19, whereas acid mucopolysaccharides promoted tumour growth20–29.
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MEHRISHI, J. Cell Surface Charge Increase by both Tumour Inhibitory and Tumour Growth Promoting Polyanions. Nature 228, 364–365 (1970). https://doi.org/10.1038/228364a0
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DOI: https://doi.org/10.1038/228364a0
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