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Relevance of Feedback Inhibition applied to the Biosynthesis of Hexosamines

Nature volume 228, pages 1311–1313 (1970)Cite this article

Abstract

NEGATIVE feedback inhibition has been demonstrated in the biosynthesis of hexosamines, where the end product, UDP-N-acetylglucosamine, potently inhibits the first enzyme of the sequence, L-glutamine D-fructose-6-phosphate aminotransferase (glucosamine-6-phosphate synthetase, EC 2.6.1.16)1,2. But to test if UDP-N-acetylglucosamine does indeed function as a physiological controller of the enzyme, two characteristics must be known: the cellular levels of UDP-N-acetylglucosamine and the response of the enzyme to the postulated modifier.

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Authors and Affiliations

  1. Department of Biochemistry, University College, Cardiff

    P. J. WINTERBURN

  2. Department of Biochemistry, The Medical School, Bristol, 8

    C. F. PHELPS

Authors
  1. P. J. WINTERBURN
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  2. C. F. PHELPS
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WINTERBURN, P., PHELPS, C. Relevance of Feedback Inhibition applied to the Biosynthesis of Hexosamines. Nature 228, 1311–1313 (1970). https://doi.org/10.1038/2281311a0

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  • DOI: https://doi.org/10.1038/2281311a0

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