Abstract
9-β-D-arabinofuranosyladenine (ara-A) is a nucleoside antibiotic (Fig. 1) with a broad spectrum of activity against animal viruses1–7 and little or no toxicity when administered parenterally to animals. The LD50 for an intraperitoneal injection is 4,677 mg/kg7. The rodent malarial parasite, Plasmodium berghei, resembles viruses in that it is an intracellular parasite. Moreover, the host is protected by interferon8. There is evidence that P. berghei utilizes part of the host protein synthesizing system9,10.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schabel, jun., F. M., Chemotherapy, 13, 321 (1968).
Miller, F. A., Dixon, G. J., Ehrlich, J., Sloan, B. J., and McLean, jun., I. W., Antimicrob. Agents Chemother., 136 (1968).
Sidwell, R. W., Dixon, G. J., Schabel, jun., F. M., and Kaump, D. H., Antimicrob. Agents Chemother., 148 (1968).
Schardein, J. L., and Sidwell, R. W., Antimicrob. Agents Chemother., 158 (1968).
Sloan, B. J., Miller, F. A., Ehrlich, J., McLean, jun., I. W., and Machamer, H. E., Antimicrob. Agents Chemother, 161 (1968).
Dixon, G. J., Sidwell, R. W., Miller, F. A., and Sloan, B. J., Antimicrob. Agents Chemother., 172 (1968).
Kurtz, S. M., Fusken, R. A., Kaump, D. H., and Schardein, J. L., Antimicrob. Agents Chemother., 180 (1968).
Jahiel, R. I., Vilcek, J., Nussenweig, R., and Vanberberg, J., Science, 161, 103 (1968).
Tokuyasu, K., Ilan, J., and Ilan, Judith, Military Med., 134, 1032 (1969).
Ilan, Judith, and Ilan, J., Science, 164, 560 (1969).
Furth, J. J., and Cohen, S. S., Cancer Res., 27, 1528 (1967).
Wellde, B. T., Briggs, N. T., and Sadun, E. H., Military Med., 131, 9 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ILAN, J., TOKUYASU, K. & ILAN, J. Phosphorylation of D-Arabinosyl Adenine by Plasmodium berghei and its Partial Protection of Mice against Malaria. Nature 228, 1300–1301 (1970). https://doi.org/10.1038/2281300a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2281300a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
