Abstract
THIS report describes an effect (not previously reported) of single doses of steroids on the cell cycle of haemopoietic stem, cells. This effect, one of increasing the sensitivity of spleen colony forming units (CFU) to the lethal effects of 3H-thymidine, is seen well before the long-term effects of steroids on erythropoiesis1. Increased sensitivity of CFU to 3H-thymidine was also observed in steroid-treated polycythaemic mice. The latter finding suggests that the steroid effect is not mediated through erythropoietin.
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BYRON, J. Effect of Steroids on the Cycling of Haemopoietic Stem Cells. Nature 228, 1204 (1970). https://doi.org/10.1038/2281204a0
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DOI: https://doi.org/10.1038/2281204a0
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