Abstract
The converting enzyme content of isolated tissues suggests that the indirect action of angiotensin I involves the intramural generation of angiotensin II. Inhibition of the enzyme shows that there is also a residual, direct action of angiotensin I.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Skeggs, L. T., Marsh, W. H., Kahn, J. R., and Shumway, N. P., J. Exp. Med., 99, 275 (1954).
Skeggs, L. T., Kahn, J. R., and Shumway, N. P., J. Exp. Med., 103, 295 (1956).
Ng, K. K. F., and Vane, J. R., Nature, 216, 762 (1967).
Ng, K. K. F., and Vane, J. R., Nature, 218, 144 (1968).
Bakhle, Y. S., Reynard, A. M., and Vane, J. R., Nature, 222, 956 (1969).
Page, I. H., and Bumpus, F. M., Physiol. Rev., 41, 331 (1951).
Huggins, C. G., and Thampi, N. S., Life Sci., 7, 633 (1968).
Bakhle, Y. S., Nature, 220, 919 (1968).
Thurau, K., Abstracts of General Sessions, IVth International Congress of Nephrology, Stockholm, Sweden, 129 (1969).
Roth, M., Weitzman, A. F., and Piquilloud, Y., Experientia, 25, 1247 (1969).
Helmer, O. M., Amer. J. Physiol., 188, 571 (1957).
Carlini, E. A., Picarelli, Z. P., and Prado, J. L., Bull. Soc. Chim. Biol., 40, 1825 (1958).
Halvorsen, K. A., Fasciolo, J. C., Calvo, R., Puebla, M., Binia, A., Alonso, F., and Fernandez, O., Rev. Soc. Argent. Biol., 34, 192 (1958).
Barrett, J. D., and Sambhi, M. P., J. Pharmacol. Exp. Therap., 170, 326 (1969).
Ng, K. K. F., and Vane, J. R., Nature, 225, 1144 (1970).
Ferreira, S. H., Brit. J. Pharmacol. Chemotherap., 24, 163 (1965).
Ferreira, S. H., Bartelt, D. C., and Greene, L. J., Biochemistry (in the press).
Ferreira, S. H., Greene, L. J., Alabaster, V. A., Bakhle, Y. S., and Vane, J. R., Nature, 225, 379 (1970).
Gaddum, J. H., Brit. J. Pharmacol. Chemotherap., 8, 292 (1953).
Regoli, D., and Vane, J. R., Brit. J. Pharmacol. Chemotherap., 23, 351 (1964).
Vane, J. R., Brit. J. Pharmacol. Chemotherap., 12, 344 (1957).
Gaddum, J. H., J. Physiol., 119, 363 (1953).
Oparil, S., Sanders, C. A., and Haber, E., Circulation Res., 26, 591 (1970).
Cain, M. D., Catt, K. J., and Coghlan, J. P., Nature, 223, 617 (1969).
Boyd, G. W., London, J., and Peart, W. S., Lancet, ii, 1002 (1967).
Catt, K., and Coghlan, J. P., Austral. J. Exp. Biol. Med. Sci., 45, 269 (1967).
Vallotton, M. B., Page, L. B., and Haber, E., Nature, 215, 714 (1967).
Dengler, J., Arch. Exp. Path. Pharmak., 227, 481 (1956).
Gould, A. B., Skeggs, L. T., and Kahn, J. R., J. Exp. Med., 119, 389 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
AIKEN, J., VANE, J. The Renin–Angiotensin System: Inhibition of Converting Enzyme in Isolated Tissues. Nature 228, 30–34 (1970). https://doi.org/10.1038/228030a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/228030a0
This article is cited by
-
Primary structure and biological activity of bradykinin potentiating peptides fromBothrops insularis snake venom
Journal of Protein Chemistry (1990)
-
Probable involvement of vascular angiotensin II formation in the β2-adrenoceptor-mediated facilitation of the neurogenic vasopressor response in the pithed rat
Naunyn-Schmiedeberg's Archives of Pharmacology (1988)
-
Subendothelial ? 2-adrenoceptors in the rat vena cava: Facilitation of noradrenaline release via local stimulation of angiotensin II synthesis
Naunyn-Schmiedeberg's Archives of Pharmacology (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.