Abstract
The DNA cistrons that code for tRNA in Escherichia coli have been isolated by repeated hybridization of DNA with tRNA and fractionation of DNA–RNA hybrids and non-tRNA cistrons by chromatography on hydroxyapatite columns. The tRNA cistrons comprise 0.04–0.06 per cent of the E. coli genome and may be located contiguously on the chromosome.
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BRENNER, D., FOURNIER, M. & DOCTOR, B. Isolation and Partial Characterization of the Transfer Ribonucleic Acid Cistrons from Escherichia coli. Nature 227, 448–451 (1970). https://doi.org/10.1038/227448a0
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DOI: https://doi.org/10.1038/227448a0
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