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Increase of Radiation Induced Leukaemia in C57B1 Female Mice by Infection with Mammary Tumour Virus

Nature volume 227, pages 400–401 (1970)Cite this article

Abstract

ALTHOUGH C57B1 mice rarely develop spontaneous lymphosarcomas or lymphatic leukaemias1, they are highly responsive to the leukaemogenic action of X-rays2. Leukaemia induced in C57B1 mice by radiation can be transmitted by cell free extracts3. The agent responsible for such transmission is a virus (radiation leukaemia virus), which, rather than radiation itself, seems to be the inducing agent of leukaemia in irradiated C57B1 mice4. Important corollaries of this conclusion are that C57B1 mice harbour an occult or latent leukaemogenic virus, and that whole body irradiation causes activation and/or release of this virus.

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Authors and Affiliations

  1. Institute of Pathological Anatomy and Histology, Medical School, University of Pisa, 56100, Pisa, Italy

    FRANCESCO SQUARTINI

  2. Institute of Pathological Anatomy and Histology, Division of Cancer Research, University of Perugia, 06100, Perugia, Italy

    GIOVANNI B. BOLIS

Authors
  1. FRANCESCO SQUARTINI
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  2. GIOVANNI B. BOLIS
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SQUARTINI, F., BOLIS, G. Increase of Radiation Induced Leukaemia in C57B1 Female Mice by Infection with Mammary Tumour Virus. Nature 227, 400–401 (1970). https://doi.org/10.1038/227400a0

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