Abstract
TRANSLOCATION, the movement of the ribosome along mRNA, is an active process which requires the hydrolysis of GTP and the participation of the soluble protein, G factor1–5. The discovery6,7 that fusidic acid, an antibiotic inhibitor of translocation, stabilizes a, complex involving ribosomes, G factor, and GDP provides a new and powerful tool with which to investigate the interaction among these participants in translocation and to provide at least indirect insight into the mechanism of this step in protein synthesis.
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BODLEY, J., LIN, L. Interaction of E. coli G Factor with the 50S Ribosomal Subunit. Nature 227, 60–62 (1970). https://doi.org/10.1038/227060a0
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DOI: https://doi.org/10.1038/227060a0
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