Abstract
THE receptors for the neurotransmitter in sympathetic ganglia (acetylcholine) are usually thought to be located exclusively on the postsynaptic membrane. Koelle1,2 has suggested, however, that the presynaptic nerve terminals are also sensitive to acetylcholine, and that, during normal transmission, the acetylcholine initially released by the preganglionic nerve impulse might depolarize the terminals and release a further quantity of acetylcholine, so amplifying the transmitter release process. Koelle recognized that this hypothesis was similar to that advanced in connexion with transmitter release from adrenergic fibres3, and suggested that such “cholinergic links” may be a widespread feature of neurotransmitter and neurosecretory systems.
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BROWN, D., JONES, K., HALLIWELL, J. et al. Evidence against a Presynaptic Action of Acetylcholine during Ganglionic Transmission. Nature 226, 958–959 (1970). https://doi.org/10.1038/226958a0
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DOI: https://doi.org/10.1038/226958a0
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