Abstract
NUMEROUS reports have documented the response of sensitized peritoneal exudate cells to various antigens, including PPD, BCG and ovalbumin1–8. By contrast, migration inhibition studies of sensitized peripheral lymphocytes without the addition of macrophages have either been inconsistent or negative9,10. Johanovsky, using a splenic explant system, obtained consistent migration inhibition to a number of particulate and soluble antigens; his system did, however, contain a number of different cell types11. The previous reports by Bendixen and Søborg that the migration of sensitized human leucocytes could be inhibited by various particulate antigens such as Brucella or organ extracts suggested that the sensitized lymphocyte could, in fact, respond to an antigenic stimulus provided the antigen was in a certain form12–14. The concept of a particular antigenic configuration being required for the stimulation of the sensitized lymphocyte was further confirmed by our consistent observation of the inhibition of migration of sensitized lymphocytes to transplantation antigens, streptococcal structures, and heterologous erythrocytes (refs. 15, 16 and our unpublished work). In each case the presence of a particulate form of the antigen seemed to be indispensable for inhibition of migration.
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ZABRISKIE, J., FALK, R. In vitro Reactivity of Lymphocytes to Particulate and Soluble Antigens. Nature 226, 943–945 (1970). https://doi.org/10.1038/226943a0
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DOI: https://doi.org/10.1038/226943a0
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