Abstract
Landsteiner and Chase1 established the cellular basis of delayed hypersensitivity when they showed that the passive transfer of the delayed-type reaction from sensitized guinea-pigs to normal animals could be achieved with peritoneal exudate but not with serum. This immunological response can be measured in vitro, for the migration of non-sensitized macrophages can be inhibited by a migration inhibitory factor (MIF) produced by sensitized lymphocytes cultured in the presence of specific antigens2,3. Intradermal injection of MIF into non-sensitized guinea-pigs produces reactions characterized by induration, erythema and mononuclear infiltration.
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References
Landsteiner, K., and Chase, M. W., Proc. Soc. Exp. Biol. Med., 49, 688 (1942).
George, M., and Vaughan, J. H., Proc. Soc. Exp. Biol. Med., 111, 514 (1962).
David, J. R., Al-Askari, S., Lawrence, H. S., and Thomas, L., J. Immunol., 93, 264 (1964).
Reisfeld, R. A., and Small, P. A., Science, 152, 1253 (1966).
Bennet, B., and Bloom, B. R., Proc. US Nat. Acad. Sci., 59, 756 (1968).
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YOSHIDA, T., REISFELD, R. Two Fractions with Macrophage Migration Inhibitory Activity from Sensitized Lymphocyte Cultures. Nature 226, 856–857 (1970). https://doi.org/10.1038/226856a0
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DOI: https://doi.org/10.1038/226856a0
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