Abstract
MENTAL retardation is consistently found in the non-phenylketonuric children of phenylketonuric mothers.1 Attempts to duplicate this effect in laboratory animals, however, have either failed to demonstrate a learning impairment or produced results in which the treatment effect is confounded with general maternal malnutrition (see ref. 2). The techniques used to induce phenylketonuria (PKU) in animals also failed to duplicate the high ratio of serum phenylalanine to tyrosine which is characteristic of the human condition.
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References
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BUTCHER, R. Learning Impairment associated with Maternal Phenylketonuria in Rats. Nature 226, 555–556 (1970). https://doi.org/10.1038/226555a0
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DOI: https://doi.org/10.1038/226555a0
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