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Interaction between Guanosine Derivatives and Factors involved in the Initiation of Protein Synthesis

Nature volume 226, pages 505–510 (1970)Cite this article

Abstract

Initiation factor C (f2) is specifically protected against heat inactivation by GTP or GDP. Interaction of this factor not only with 70S ribosomes but also with 30S subunits leads to a specific hydrolysis of GTP which is stimulated by adding both initiator codon and rRNA. Initiation factor A (f1) inhibits the GTP splitting by the 30S–factor C–initiation complex.

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Authors and Affiliations

  1. Institut de Biologie Physico-Chimique (Services de Physiologie Microbienne et de Biochimie), rue Pierre Curie, Paris

    J. C. LELONG, M. GRUNBERG-MANAGO, J. DONDON, D. GROS & F. GROS

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  1. J. C. LELONG
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  2. M. GRUNBERG-MANAGO
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  3. J. DONDON
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  4. D. GROS
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  5. F. GROS
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LELONG, J., GRUNBERG-MANAGO, M., DONDON, J. et al. Interaction between Guanosine Derivatives and Factors involved in the Initiation of Protein Synthesis. Nature 226, 505–510 (1970). https://doi.org/10.1038/226505a0

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