Abstract
THE inactive-X hypothesis states that only one of the two X chromosomes in each somatic cell of adult mammalian females is genetically active. The initial event in early embryogenesis which determines whether the paternal or the maternal X chromosome will remain active in any given cell is presumably random; once made, the choice is fixed for that cell and for all its descendants1–4. Although this type of inactivation has been demonstrated in man for a number of X-linked loci5, it is not known whether the entire X chromosome is inactivated.
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FIALKOW, P., LISKER, R., GIBLETT, E. et al. Xg Locus : Failure to detect Inactivation in Females with Chronic Myelocytic Leukaemia. Nature 226, 367–368 (1970). https://doi.org/10.1038/226367a0
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DOI: https://doi.org/10.1038/226367a0
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