Abstract
THE antifertility effect in rats of α-chlorhydrin (3-chloro-1,2-propanediol, U-5897, I) is well established1,2 and our studies3 suggested that glycidol (2,3-epoxypropane-l-ol, II) could be an active metabolite. In rats, it has now been shown that glycidol, like α-chlorhydrin, produces a functional type of sterility through an effect on epididymal sperm, induces spermatoceles and follows a similar metabolic pathway.
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JACKSON, H., CAMPBELL, I. & JONES, A. Is Glycidol an Active Intermediate in the Antifertility Action of α-Chlorhydrin in Male Rats?. Nature 226, 86–87 (1970). https://doi.org/10.1038/226086a0
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DOI: https://doi.org/10.1038/226086a0
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