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Australia Antigen–Antibody Complexes

Nature volume 226, pages 83–84 (1970)Cite this article

Abstract

BLUMBERG and his colleagues have published data on the relation of Australia antigen, Au(1), to hepatitis1,2. While existing antisera, either of human or rabbit sources3, frequently can be used to detect this antigen in patients with hepatitis by either immunodiffusion4 or complement fixation5 it is probable that the antigen is undetectable in some patients. One possible reason for this may be the neutralization of antigen by antibody. Sera may manifest the presence of antigen at one time and antibody at another time2. In such a case, a precipitin band forms between sera from early and later bleedings from the same patient.

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References

  1. Blumberg, B. S., Alter, H. E., and Visnich, S., J. Amer. Med. Assoc., 191, 541 (1967).

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  2. Blumberg, B. S., Sutnick, A. I., and London, W. T., Bull. NY Acad, Med., 44, 1566 (1968).

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  3. Melartin, L., and Blumberg, B. S., Nature, 210 1340 (1966).

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Authors and Affiliations

  1. Institute for Cancer Research, Fox Chase, Philadelphia, Pennsylvania, 19111

    IRVING MILLMAN, W. THOMAS LONDON, ALTON I. SUTNICK & BARUCH S. BLUMBERG

Authors
  1. IRVING MILLMAN
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  2. W. THOMAS LONDON
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  3. ALTON I. SUTNICK
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  4. BARUCH S. BLUMBERG
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MILLMAN, I., LONDON, W., SUTNICK, A. et al. Australia Antigen–Antibody Complexes. Nature 226, 83–84 (1970). https://doi.org/10.1038/226083a0

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