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Failure to detect an Antigen associated with Hepatitis in a Community Epidemic

Nature volume 225, pages 953–955 (1970)Cite this article

Abstract

HEPATITIS associated antigen (HAA) (Australian antigen1, SH antigen2) is often demonstrable in the serum of cases of serum hepatitis. HAA is also reported in infectious hepatitis, although with lesser frequency3–5. The latter observations, however, are in contrast with the finding by Giles and co-workers6. None of the children at Willow-brook State School developed HAA in their sera after inoculation with an agent (MS–1) having the characteristics of IH virus. The apparent discrepancy can be resolved only by additional observations using specimens from epidemiologically well characterized cases.

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Author information

Authors and Affiliations

  1. Epidemiology and Research Analysis Branch, Foreign Quarantine Program, National Communicable Disease Center, Atlanta, Georgia

    JAMES W. MOSLEY

  2. Laboratory of Viral Immunology, Division of Biological Standards, National Institutes of Health, Bethesda, Maryland

    LEWELLYS F. BARKER

  3. Clinical Haematology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

    N. RAPHAEL SHULMAN

  4. Enteric Virology Unit, Laboratory Division, National Communicable Disease Center, Atlanta, Georgia

    MILFORD H. HATCH

Authors
  1. JAMES W. MOSLEY
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  2. LEWELLYS F. BARKER
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  3. N. RAPHAEL SHULMAN
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  4. MILFORD H. HATCH
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MOSLEY, J., BARKER, L., SHULMAN, N. et al. Failure to detect an Antigen associated with Hepatitis in a Community Epidemic. Nature 225, 953–955 (1970). https://doi.org/10.1038/225953a0

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