Abstract
ASTALDI et al.1 reported that Escherichia coli L-asparaginase inhibited the blast transformation characteristic of cultures of lymphocytes stimulated by phytohaemagglutinin, a finding which was promptly confirmed by the investigation of McElwain and Hayward2. In view of this observation and the known inhibition of protein synthesis3 by asparaginase, it seemed likely that this anti-tumour agent might also inhibit antibody formation during the primary immune response. To examine this possibility, mice receiving asparaginase were immunized with human erythrocytes (RBC), and their haemagglutinin titres were compared with those of untreated mice.
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References
Astaldi, G., Burgio, G. R., Krč, J., Genova, R., and Astaldi, A. A., Lancet i, 423 (1969).
McElwain, T. J., and Hayward, S. K., Lancet, i, 527 (1969).
Sobin, L. H., and Kidd, J. G., J. Exp. Med., 123, 55 (1966).
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PRAGER, M., DERR, I. Inhibition of Primary Antibody Response by E. coli Asparaginase. Nature 225, 952 (1970). https://doi.org/10.1038/225952a0
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DOI: https://doi.org/10.1038/225952a0
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