Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Histocompatibility and Human Placentation

Abstract

HISTOCOMPATIBILITY antigens were recently suggested by Jones1 to affect human placentation. His observation was based on data of maternal ABO blood groups and placental weights. The immunological disparity of the mother and her foetus was found to be associated with a relatively smaller placenta and vice versa. The expected proportion of ABO incompatible pregnancies for each maternal blood group was calculated from the ABO gene frequencies in the population2.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jones, W. R., Nature, 218, 480 (1968).

    Article  ADS  CAS  Google Scholar 

  2. Dobson, A. M., and Ikin, E., J. Path. Bact., 48, 221 (1946).

    Article  Google Scholar 

  3. Llewellyn-Jones, D., J. Obst. Gynaec. Brit. Comm., 72, 242 (1965).

    Article  CAS  Google Scholar 

  4. Scott, J. S., Amer. J. Obst. Gynec., 83, 185 (1962).

    Article  CAS  Google Scholar 

  5. Mogensen, B., and Kissmeyer-Nielsen, F., Scand. Symp. Immunol., 19 (Swedish Soc. Microbiol., Stockholm, 1969).

  6. Azar, H. A., Cancer, 15, 66 (1962).

    Article  CAS  Google Scholar 

  7. Iliya, F. A., Williamson, S., and Azar, H. A., Cancer, 20, 144 (1967).

    Article  CAS  Google Scholar 

  8. Currie, G. A., and Bagshawe, K. D., Lancet, i, 708 (1967).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

SEPPÄLÄ, M., TOLONEN, M. Histocompatibility and Human Placentation. Nature 225, 950–951 (1970). https://doi.org/10.1038/225950a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/225950a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing