Abstract
STANLEY et al. reported the production of a lymphoma (2731/L) in Prince Henry (PH) mice after inoculation with spleen cells from a PH mouse with chronic (272 days) reovirus type 3 infection1. They suggested a relationship between reoviruses and the tumour. From recent data on the prevalence of murine leukaemia virus in most mouse strains2, we would conclude that lymphomas induced in mice can, with considerable certainty, be attributed to murine leukaemia (C-type RNA) viruses in the passage materials. We have therefore tested for the presence of a murine leukaemia virus in the 2731/L tumour as well as other mouse lymphomas developing after various procedures (Table 1) in Stanley's PH line.
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References
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LEVY, J., HUEBNER, R. Association of Murine Leukaemia Virus from a Mouse Lymphoma (2731/L) with Reovirus Type 3 Infection. Nature 225, 949–950 (1970). https://doi.org/10.1038/225949a0
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DOI: https://doi.org/10.1038/225949a0
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