Abstract
NUCLEAR magnetic resonance (NMR) spectroscopy is one of the most promising techniques to be recently applied to the study of lipid, protein and water interactions in biological and other ordered and semi-ordered systems. NMR studies of the water in many hydrated biological systems have been interpreted in terms of the existence of “structured”, “ice-like” or “bound” water1–6. Likewise, line broadening in ordered liquid crystalline and biological systems has often been taken as an indication of restriction of molecular motion7–13. We should like to point out some possible pitfalls in interpreting the results of limited relaxation or line width data in terms of changes in molecular mobility arising from specific interactions, in systems which are not isotropic liquids and are not always homogeneous. We have carried out a spin-echo NMR study of the dimethyldodecylamine oxide–deuterium oxide system—a system in which anisotropic ordered structures exist and one for which considerable X-ray and continuous wave NMR data are available9,14. This system is an ideal one for the study of the effects of molecular ordering and anisotropy on the measured NMR parameters because the structure can be changed from isotropic to anisotropic simply by a slight change in composition or temperature.
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HANSEN, J., LAWSON, K. Magnetic Relaxation in Ordered Systems. Nature 225, 542–544 (1970). https://doi.org/10.1038/225542a0
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DOI: https://doi.org/10.1038/225542a0
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