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Acute Childhood Leukaemia in Relation to the HL–A Human Transplantation Genes

Nature volume 225, pages 461–462 (1970)Cite this article

Abstract

THE expectation that certain human diseases might show a high statistical correlation with certain transplantation genes is based on analogy with mouse systems1. The H–2b gene in mice is associated with a low incidence of tumours and with great longevity in three different inbred strains2. Another transplantation gene, the H–2k gene, confers in homozygous form an almost 100 per cent susceptibility to the Gross leukaemia virus3 and a non-susceptibility to the Tennant leukaemia virus4.

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References

  1. Walford, R. L., The Isoantigenic Systems of Human Leukocytes: Medical and Biological Significance (Munksgaard, Copenhagen, 1969).

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  2. Walford, R. L., The Immunologic Theory of Aging (Munksgaard, Copenhagen, 1969).

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  3. Lilly, F., Boyse, E. A., and Olds, L. J., Lancet, ii, 1207 (1964).

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  5. Kourilsky, F. M., Dausset, J., Feingold, J., Dupuy, J. M., and Bernard, J., Advances in Transplantation, 515 (Munksgaard, Copenhagen, 1968).

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  6. Troup, G. M., and Walford, R. L., Amer. J. Clin. Pathol., 51, 529 (1969).

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Authors and Affiliations

  1. Departments of Pathology and Pediatrics, UCLA Medical Center, Los Angeles

    ROY L. WALFORD, SIMON FINKELSTEIN, ROBERT NEERHOUT, PAT KONRAD & EDWARD SHANBROM

  2. the Research Division, Hyland Laboratories,

    ROY L. WALFORD, SIMON FINKELSTEIN, ROBERT NEERHOUT, PAT KONRAD & EDWARD SHANBROM

Authors
  1. ROY L. WALFORD
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  2. SIMON FINKELSTEIN
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  3. ROBERT NEERHOUT
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  4. PAT KONRAD
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  5. EDWARD SHANBROM
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WALFORD, R., FINKELSTEIN, S., NEERHOUT, R. et al. Acute Childhood Leukaemia in Relation to the HL–A Human Transplantation Genes. Nature 225, 461–462 (1970). https://doi.org/10.1038/225461a0

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