Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Restoration of In-phase Translation by an Unlinked Suppressor of a Frameshift Mutation in Salmonella typhimurium

Abstract

When carrying an unlinked suppressor, a frameshift mutant produces small quantities of wild-type protein.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Whitfield, H. J., Martin, R. G., and Ames, B. N., J. Mol. Biol., 21, 335 (1966).

    Article  CAS  PubMed  Google Scholar 

  2. Riyasaty, S., and Atkins, J. F., J. Mol. Biol., 34, 541 (1968).

    Article  CAS  PubMed  Google Scholar 

  3. Oeschger, N., and Hartman, P. E., J. Bact. (in, the press).

  4. Yourno, J., Barr, D., and Tanemura, S., J. Bact., 100, 453 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Yourno, J., and Heath, S., J. Bact., 100, 460 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Tanemura, S., and Yourno, J., J. Mol. Biol., 46, 459 (1970).

    Article  Google Scholar 

  7. Fink, G. R., Klopotowski, T., and Ames, B. N., J. Mol. Biol., 30, 81 (1967).

    Article  CAS  PubMed  Google Scholar 

  8. Yourno, J., and Ino, I., J. Biol. Chem., 243, 3273 (1968).

    CAS  PubMed  Google Scholar 

  9. Canfield, R. E., and Anfinsen, C. B., in The Proteins (edit. by Neurath, H.), 1, 319 (Academic Press, New York, 1963).

    Google Scholar 

  10. Yourno, J., J. Mol. Biol. (in the press).

  11. Carbon, J., Berg, P., and Yanofsky, C., Proc. US Nat. Acad. Sci., 56, 764 (1966).

    Article  ADS  CAS  Google Scholar 

  12. Gupta, N. K., and Khorana, H. G., Proc. US Nat. Acad. Sci., 56, 772 (1966).

    Article  ADS  CAS  Google Scholar 

  13. Capecchi, M. R., and Gussin, G. N., Science, 149, 416 (1965).

    Article  ADS  Google Scholar 

  14. Englehardt, D. L., Webster, R. E., Wilhelm, R. C., and Zinder, N. D., Proc. US Nat. Acad. Sci., 54, 1791 (1965).

    Article  ADS  Google Scholar 

  15. Goodman, H. M., Ableson, J., Landy, A., Brenner, S., and Smith, J. D., Nature, 217, 1019 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Magni, G. E., von Borstel, R. C., and Steinberg, C., J. Mol. Biol., 16, 568 (1966).

    Article  CAS  PubMed  Google Scholar 

  17. Streisinger, G., Okada, Y., Emrich, J., Newton, J., Tsugita, A., Terghaghi, E., and Inouye, M., Cold Spring Harbor Symp. Quant. Biol., 31, 77 (1966).

    Article  CAS  PubMed  Google Scholar 

  18. Crick, F. H. C., J. Mol. Biol., 19, 548 (1966).

    Article  CAS  PubMed  Google Scholar 

  19. Brenner, S., Barnett, L., Katz, E. R., and Crick, F. H. C., Nature, 213, 449 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Weigert, M. G., Lanka, E., and Garen, A., J. Mol. Biol., 21, 335 (1966).

    Article  Google Scholar 

  21. Gorini, L., Jacoby, G. A., and Breckenridge, L., Cold Spring Harbor Symp. Quant. Biol., 28, 657 (1966).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

YOURNO, J., TANEMURA, S. Restoration of In-phase Translation by an Unlinked Suppressor of a Frameshift Mutation in Salmonella typhimurium. Nature 225, 422–426 (1970). https://doi.org/10.1038/225422a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/225422a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing