Abstract
THE earliest lesion in the cerebellum of sheep affected with natural scrapie is a degeneration of the mossy terminals within the granular layer of the cerebellar cortex1,2. With this in mind we have made a combined electron and light microscope study of these early lesions. We used sheep from a supervised breeding population, the normal controls being genetically non-susceptible to natural scrapie3.
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BIGNAMI, A., BECK, E. & PARRY, H. Neurosecretion-like Material in the Hindbrain of Ageing Sheep and Sheep affected with Natural Scrapie. Nature 225, 194–196 (1970). https://doi.org/10.1038/225194a0
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DOI: https://doi.org/10.1038/225194a0
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