Abstract
IT has been shown that BALB/c mice infected with Moloney leukaemogenic virus develop a higher incidence of leukaemias and lymphomas, after a shorter latent period, when they are treated with antilymphocytic serum (ALS) than in the absence of ALS1,2. We therefore considered it of interest to examine the effects of ALS on a strain of mice in which lymphomas occur naturally without infection by any exogenous virus. Mice of the strain SJL/J spontaneously develop a high incidence of reticular neoplasms3–5, which are of the pleiomorphic type B described by Dunn6. In untreated mice, neoplasms begin to appear when they are about 1 year old and the cumulative incidence before death is over 70 per cent.
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BURSTEIN, N., ALLISON, A. Effect of Antilymphocytic Serum on the Appearance of Reticular Neoplasms in SJL/J Mice. Nature 225, 1139–1140 (1970). https://doi.org/10.1038/2251139a0
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DOI: https://doi.org/10.1038/2251139a0
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