Abstract
SPECIFIC anti-tumour antibodies have now been demonstrated in human sera using several different serological techniques1–5. Except in the case of Burkitt's lymphoma6,7, however, specific anti-tumour antibodies have not been consistently detectable with the complement fixation test. Our recent immunofluorescence studies have demonstrated specific antisarcoma antibody in the serum of patients with this disease8. In attempting to detect these antisarcoma antibodies by complement fixation, it was noted that they could be demonstrated only if cells derived from cultured human sarcoma cells were used as antigen and fresh human serum was used as a source of complement. This report describes the conditions necessary for the demonstration of these anti-tumour antibodies in human sera.
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EILBER, F., MORTON, D. Demonstration in Sarcoma Patients of Anti-tumour Antibodies which Fix Only Human Complement. Nature 225, 1137–1138 (1970). https://doi.org/10.1038/2251137a0
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DOI: https://doi.org/10.1038/2251137a0
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