Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Size-specific Metal Complexing Sites in Native Collagen

Nature volume 225, pages 1134–1136 (1970)Cite this article

Abstract

THERE is evidence that metal ions are involved, directly and indirectly, in the structure and function of the collagens1–11. The direct interactions between collagen proteins and metal ions must be elucidated in order to understand the roles of these ions in connective tissues. One approach is to study the metal binding properties of relatively intact collagen matrices in model systems consisting of water solutions of several ionic salts. Previous experiments have involved the binding of a few ions to purified reconstituted calf-skin collagen12, egg shell matrix13, gelatine14 and bivalent amino-acids15.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Chvapil, M., and Hurych, J., International Review of Connective Tissue Research (edit. by Hall, D. A.), 4 (Academic Press, New York and London, 1968).

    Google Scholar 

  2. Bornstein, P., Kang, A. H., and Piez, K. A., Proc. US Nat. Acad. Sci., 55, 475 (1966).

    Article  Google Scholar 

  3. O'Dell, B. L., et al., Nature, 209, 401 (1966).

    Article  ADS  CAS  Google Scholar 

  4. Prockop, D. J., and Juva, K., Proc. US Nat. Acad. Sci., 53, 661 (1965).

    Article  ADS  CAS  Google Scholar 

  5. Urist, M. R., and Abernethy, J. L., Clin. Ortho. Rel. Res., 51, 255 (1967).

    Google Scholar 

  6. Steven, F. S., Biochim. Biophys. Acta, 140, 552 (1967).

    Article  Google Scholar 

  7. Sobel, A. E., and Hanok, A., J. Biol. Chem., 197, 669 (1952).

    CAS  PubMed  Google Scholar 

  8. Becker, R. O., Spadaro, J. A., and Berg, E. W., J. Bone Joint Surg., 50-A, 326 (1968).

    Article  CAS  Google Scholar 

  9. Ellis, E. H., Spadaro, J. A., and Becker, R. O., Clin. Ortho. Rel. Res., 65, 195 (1969).

    Article  CAS  Google Scholar 

  10. Wadkins, C. L., Calc. Tiss. Res., 2, 214 (1968).

    Article  CAS  Google Scholar 

  11. Schiffman, E., Corcoran, B. A., and Martin, G. R., Arch. Biochem. Biophys., 115, 87 (1966).

    Article  Google Scholar 

  12. Weinstock, A., King, P. C., and Wuthier, R. E., Biochem. J., 102, 983 (1967).

    Article  CAS  Google Scholar 

  13. Simkiss, K., and Tyler, C., Quart. J. Microsc. Sci., 99, 5 (1958).

    Google Scholar 

  14. Bello, J., Biochim. Biophys. Acta, 109, 250 (1965).

    Article  CAS  Google Scholar 

  15. Albert, A., Biochem. J., 47, 531 (1950).

    Article  CAS  Google Scholar 

  16. Pauling, L., The Nature of the Chemical Bond (Cornell University Press, Ithaca, 1960).

    MATH  Google Scholar 

  17. Chaberek, S., and Martell, A. E., Organic Sequestering Agents, 169, 112 (John Wiley and Sons, Inc., New York, 1959).

    Google Scholar 

  18. Ionization data from: Handbook of Chemistry and Physics (edit. by West, R. C.) (Chemical Rubber Co., Cleveland, 1968).

  19. Keller, R. N., and Parry, R. W., The Chemistry of Coordination Compounds (edit. by Bailar, J. C.), chap. 4 (Reinhold Publishing Co., New York, 1956).

    Google Scholar 

  20. Dwyer, F. P., and Mellor, D. P., Chelating Agents and Metal Chelates, chap. 2 (Academic Press, New York and London 1964).

    Google Scholar 

  21. Veis, A., Treatise on Collagen (edit. by Ramachandran), 1 (Academic Press, London and New York, 1967).

    Google Scholar 

  22. Rosmus, J., et al., Experientia, 23, 898 (1967).

    Article  CAS  Google Scholar 

  23. Dunstone, J. R., Biochem. J., 72, 465 (1959).

    Article  CAS  Google Scholar 

  24. Molinari-Tosatti, et al., Clac. Tiss. Res., 2 (suppl.), 88 (1968).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Veterans Administration Hospital, Syracuse, NY

    JOSEPH A. SPADARO & ROBERT O. BECKER

  2. Department of Physics, Syracuse University, Syracuse, NY

    CHARLES H. BACHMAN

Authors
  1. JOSEPH A. SPADARO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. ROBERT O. BECKER
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. CHARLES H. BACHMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SPADARO, J., BECKER, R. & BACHMAN, C. Size-specific Metal Complexing Sites in Native Collagen. Nature 225, 1134–1136 (1970). https://doi.org/10.1038/2251134a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2251134a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing