Abstract
AN understanding of the primary structures of the large ribosomal RNAs should lead to greater insight into the structure of ribosomes and the way in which they work. Nucleotide sequences within the 16S RNA of Escherichia coli have recently been studied1, but little is known about the primary structure of the 23S RNA (refs. 2–5). Two sorts of observations have been reported, however, which might be of general significance in considering the structure and evolution of this molecule: (a) The 23S and 16S ribosomal RNAs of E. coli have been found to compete with each other in hybridizing with E. coli DNA (refs. 6–9). This would indicate that they share some nucleotide sequences in common, (b) It has been suggested that the nucleotide sequences in the neighbourhood of the methylated nucleotides each occur twice within the 23S RNA (refs. 2, 3), implying that sequence repetition could be widespread.
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FELLNER, P., EBEL, J. Biological Sciences: Observations on the Primary Structure of the 23S Ribosomal RNA from E. coli. Nature 225, 1131–1132 (1970). https://doi.org/10.1038/2251131a0
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DOI: https://doi.org/10.1038/2251131a0
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