Abstract
SUBACUTE sclerosing panencephalitis (SSPE), a progressive neurological disease of children, is characterized by intracytoplasmic and intranuclear inclusions in the neurones and glial cells. Although no infectious agent was isolated directly from the diseased brain tissue, a paramyxovirus, related serologically to the measles–rinderpest virus group, was recovered from SSPE brain cells maintained in tissue culture in serial passages1. These cultures were characterized by the formation of syncytia and by their capacity to undergo transformation2. Only by fusion with African green monkey kidney cells (AGMK) could an infectious syncytiogenic paramyxovirus be recovered from the brain cells.
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KOPROWSKI, H., BARBANTI-BRODANO, G. & KATZ, M. Interaction between Papova-like Virus and Paramyxovirus in Human Brain Cells: a Hypothesis. Nature 225, 1045–1047 (1970). https://doi.org/10.1038/2251045a0
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DOI: https://doi.org/10.1038/2251045a0
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