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Hydra as a Biological Amplifier for testing the Thiol Agent Azoester

Nature volume 224, pages 717–718 (1969)Cite this article

Abstract

THE feeding behaviour of freshwater hydra1 presents a readily observable criterion for evaluating the effects of biologically active compounds. We have utilized the thiol agent, azoester (methyl phenyldiazenecarboxylate, C6H5N = NCOOCH3), in order to examine the behavioural consequences of intracellular oxidation of glutathione (GSH) to the corresponding disulphide (GSSG) on the hydra. The chemical and biological properties of azoester and related thiol agents have been reviewed already2–4.

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References

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Authors and Affiliations

  1. Departments of Polymer Science, Biophysics and Biological Ultrastructure, Weizmann Institute of Science, Rehovot, Israel

    HOWARD M. LENHOFF, EDWARD M. KOSOWER & NECHAMA S. KOSOWER

  2. Department of Organismic Biology, University of California, Irvine, California, 92664

    HOWARD M. LENHOFF

  3. Department of Chemistry, State University of New York, Stony Brook, New York, 11790

    EDWARD M. KOSOWER

  4. Department of Medicine, Albert Einstein College of Medicine, New York, 10461

    NECHAMA S. KOSOWER

Authors
  1. HOWARD M. LENHOFF
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  2. EDWARD M. KOSOWER
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  3. NECHAMA S. KOSOWER
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LENHOFF, H., KOSOWER, E. & KOSOWER, N. Hydra as a Biological Amplifier for testing the Thiol Agent Azoester. Nature 224, 717–718 (1969). https://doi.org/10.1038/224717a0

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  • DOI: https://doi.org/10.1038/224717a0

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