Abstract
MICE with congenital lymphocytic choriomeningitis (LCM) virus infection eventually manifest expanding lesions of the lymphoreticular system which results in glomerulonephritis1. The age-incidence and the intensity of the disease seem to vary among mouse strains, which possibly differ in host levels of viraemia, or antibody response, or both2. Germfree mice, congenitally infected with LCM virus (LCM mice), developed virus-related lesions which indicated hyperactivity of immunological mechanisms; and this was characterized by depletion of cortical thymocytes, swollen lymph nodes and spleens with very large germinal zones, infiltrations of many organs with lymphoid cells (including plasma cells), hypergammaglobulinaemia and degenerative kidney changes3,4.
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SHARON, N., POLLARD, M. Cylophosphamide Treatment of Gnotobiotic Mice congenitally infected with Lymphocytic Choriomeningitis Virus. Nature 224, 707–709 (1969). https://doi.org/10.1038/224707a0
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DOI: https://doi.org/10.1038/224707a0
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